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The most common type of vaso-occlusive disease is known as Raynaud’s syndrome. Named after the French physician Jean-Athanase Raynaud, this disorder causes a partial or complete reduction in blood supply to the fingers and toes. The resulting coldness and tingling can cause discomfort and interfere with the function of these body parts. Typically, Raynaud’s begins as a localized episode that lasts for a few days. The condition may then spread to affect other parts of the body, such as the face, upper arms, lower legs and genitalia. If left untreated, Raynaud’s can cause permanent damage to delicate areas of the body, including the heart, eyes and kidneys.